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Research Group of Metabolic Bariatric Surgery and Obesity Research (Prof. Bueter)

FIBAR

This project has been concluded in May 2021.

Scientific Report

The FIBAR Project (Effects of Dietary Fibre on Satiety in Morbidly Obese Patients Before and After Bariatric Surgery - a Single-Center, Randomised, Single-Blinded, Cross-Over Study), initiated by Prof. Marco Bueter in 2018 and concluded in 2021, explored the impact of viscous and fermentable dietary fibre on eating behaviour in morbidly obese patients before and after the Roux-en-Y Gastric Bypass (RYGB). The study examined dietary fibre’s effects on ad libitum eating behaviour, appetite perception, gastrointestinal hormone secretion, glycaemic response, and large intestinal fermentation. By investigating key mechanisms such as gastric distention, small intestinal nutrient sensing, and large intestinal fermentation, the project focused on how dietary fibre affects the production of short-chain fatty acids (SCFA), breath hydrogen as a marker of fermentation, GLP-1 and PYY secretion, and blood glucose and plasma insulin levels.
 
Key findings include:
  • RYGB surgery increased postprandial GLP-1 and PYY secretion while lowering blood glucose and plasma insulin levels.
  • Inulin appears to inhance the surgery's glucose-lowering and appetite-suppressive effects.
  • Changes in macronutrient and food intake (grams and kcal) after RYGB.
  • Insights into the role of SCFA in modulating satiety and energy homeostasis.
  • Enhanced understanding of the gut microbiome's role in eating behaviour and weight regulation.
This research underscores the role of dietary fibre in post-bariatric metabolic and appetite regulation, suggesting that RYGB accelerates large intestinal fermentation without direct effects on plasma SCFAs or gut hormones. The findings regarding inulin's effect offer new insights for optimising post-bariatric nutritional interventions and personalised dietary strategies for obesity management.
The study was approved by the Ethics Committee of Zurich with BASEC-Nr. 2017-02287.
The study is registered on ClinicalTrials.gov with ID NCT03573258 (ClincalTrials.gov).

Scientific Publications

(2024)
 
Steinert, R.E., Mueller, M., Serra, M., Lehner-Sigrist, S., Frost, G., Gero, D., Gerber, P.A., Bueter M, 2023.
Nutrition & Diabetes 6;14(1):9.